Histopathology of hepatocellular carcinoma - when and what

Histopathology of hepatocellular carcinoma.

Hepatocellular Carcinoma (HCC) is the most frequent primary liver malignancy, mostly occurring in the context of chronic liver diseases leading to cirrhosis. Epidemiological data demonstrate the increasing incidence of HCC worldwide, mainly related to viral hepatitis and metabolic syndrome. Pathological analysis recognizes several types of HCC according to macroscopic and microscopic features. ...

Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma and Hepatocellular Carcinoma Histopathology Reporting Guide

HISTOLOGICAL TUMOUR TYPE (Note 7) Hepatocellular carcinoma Hepatocellular carcinoma, fibrolamellar variant Cholangiocarcinoma Combined hepatocellular – cholangiocarcinoma Intraductal papillary neoplasm with an associated invasive carcinoma Mucinous cystic neoplasm with an associated invasive carcinoma Undifferentiated carcinoma Carcinoma, type cannot be determined mm Intrahepatic Cholangiocar...

Hepatocellular Carcinoma in Sheep

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

Screening for hepatocellular carcinoma: What is missing?

While there are guidelines from all major liver societies for the screening and management of hepatocellular carcinoma (HCC), many issues remain surrounding the actual practice of screening. This review discusses how to diagnose and screen HCC and more importantly, how well we diagnose and screen for HCC. Improved survival and outcomes after HCC diagnosis depend upon accurate diagnosis of cirrh...